Hypersusceptibility to Basal Anaesthetics

Hypersusceptibility to chemicals: risk factors for neurological disease?

Evaluation of cutpoints for phenotypic hypersusceptibility to efavirenz.

Phenotypic assays measure the susceptibility of HIV-1 to antiretroviral drugs, and are used to guide treatment regimen choices. Analyses of baseline predictors of virological failure support the use of a 0.4-fold cutpoint for defining increased susceptibility (hypersusceptibility) to efavirenz in the PhenoSense HIV assay. The enhancement of the virological activity of efavirenz, associated with...

Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics

Mycobacterium tuberculosis (M. tuberculosis) is considered innately resistant to β-lactam antibiotics. However, there is evidence that susceptibility to β-lactam antibiotics in combination with β-lactamase inhibitors is variable among clinical isolates, and these may present therapeutic options for drug-resistant cases. Here we report our investigation of susceptibility to β-lactam/β-lactamase ...

Further Studies on Bacterial Hypersusceptibility. Ii

When filtered alkaline extracts of pulverized bacteria of several varieties are precipitated with acid in the cold, boiled with acid, and all materials thrown down by these procedures removed, there remains a small amount of an alcohol-precipitable material which no longer gives any of the ordinary chemical reactions for proteins, such as the biuret, Hopkins-Cole, Millon, and sulfosalicylic aci...

Anaesthetics. With special reference to Ivan Magill.

Ivan Whiteside Magill, from Larne, is one of our most illustrious 'wild geese' (Fig 1). In 1912 as a medical student he was issued with a certificate confirming that he had, as part of his training, administered one anaesthetic (Fig 2). At that time, this was the only statutory requirement of training in anaesthesia for the qualifying examination of MB, BCh, BAO. The certificate was signed by R...